Acetylcholinesterase inhibitory potencies of new pyrazoline derivatives
نویسندگان
چکیده
منابع مشابه
Carbamyl derivatives of acetylcholinesterase.
It has recently been shown that carbamyl derivatives of acetylcholinesterase can be obtained by the reaction of the enzyme with dimethylcarbamyl fluoride, dimethylcarbamyl choline, and carbamyl choline (1). These substances inhibit the enzyme slowly and once inhibited, the enzyme recovers activity slowly upon dilution. The rate of recovery is the same when the inhibitor is either dimethylcarbam...
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A series of 2-pyrazolines 5-9 have been synthesized from α,β-unsaturated ketones 2-4. New 2-pyrazoline derivatives 13-15 bearing benzenesulfonamide moieties were then synthesized by condensing the appropriate chalcones 2-4 with 4-hydrazinyl benzenesulfonamide hydrochloride. Ethyl [1,2,4] triazolo[3,4-c][1,2,4]triazino[5,6-b]-5H-indole-5-ethanoate (26) and 1-(5H-[1,2,4]triazino[5,6-b] indol-3-yl...
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The relative inhibitory potency (RIP) of an organophosphorus (OP) inhibitor against acetylcholinesterase (AChE) versus neuropathy target esterase (NTE) may be defined as the ratio [k(i)(AChE)/k(i)(NTE)], where k(i) is the bimolecular rate constant of inhibition for a given inhibitor against each enzyme. RIPs greater than 1 correlate with the inability of ageable OP inhibitors or their parent co...
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Alguns novos derivados de pirazol-5-carbonitrila 8,9 e pirazol-5-carboxamida 13 foram sintetizados pela reação de cicloadição de nitriliminas 3,4 a α-cianocinamonitrilas 5a-f e α-cianocinamamida 12a,b, respectivamente. Por outro lado, a adição de 3,4 a α-cianocinamato de etila 14a-f leva à produção de derivados de 2-pyrazoline-5-carboxilato de etila, 15, 16. Também, a cicloadição de 3,4 à 3-cia...
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ژورنال
عنوان ژورنال: Journal of Research in Pharmacy
سال: 2020
ISSN: 2630-6344
DOI: 10.35333/jrp.2020.194